Cross-Coupling Reactions of Persistent Tertiary Carbon Radicals

The scope of cross-coupling reactions using tertiary carbon-centered radicals has expanded rapidly over the past decade. In this review, we outline development that involve persistent as a powerful toolbox to synthesize molecules containing quaternary carbon(s) and/or tetra-substituted carbon(s). particular, focus on derived from carbonyl- or related compounds. We first describe historical background and structural characterization these radicals, their reactivity/selectivity relationships. then present selected recent examples involving categorized according originally proposed reaction mechanism, showcase versatile synthetic utility for diversification small molecules. Radical-based are tools construct congested C(sp3)–C(sp3) bonds. highlight carbon generated carbonyl compounds, with emphasis role dimer/radical equilibrium. summarize reactions, grouped mode bond formation.